Validation and Inter-lab Reproducibility Testing – 126098009



Notice Number: 126098009
Date Posted: 2/24/2020
Comments Due: 3/2/2020
at 12:00 PM current Mountain Time.

The Utah Procurement Code provides that a procurement may be made without competition when the University determines that there is only one source that can reasonably meet the University’s need for the required supply or service, as described in Utah Code Ann. § 63G-6a-802.

The Purchasing Department has received the following request for sole source procurement:


Product and/or Service to be Purchased: Validation and Inter-lab Reproducibility Testing
Sole Source Supplier: TwinStrand Biosciences

Earliest Proposed Purchase Date: 3/2/2020
Buyer Name: Anthony Ferrara
Sole Source Justification:

TwinStrand Biosciences, Seattle, WA has a truly unique offering that no other company offers.  They have an extremely sensitive assay that all but eliminates PCR errors associated with NGS sequencing. This new DS-based genotoxicity assay can detect extremely rare mutations at frequencies below one-in-ten-million, and thus is sensitive enough to directly measure the faint signal of a mutagen within days of cellular exposure using only bulk-extracted genomic DNA. The true background mutation frequency of normal mammalian tissue, on the other hand, is approximately 0.00001%, five orders of magnitude lower. A set of error-correction techniques, collectively known as single stranded consensus sequencing (SSCS), improved the ability to distinguish errors from true mutations using “molecular barcoding” to apply a unique tag to individual DNA molecules within a sample and, after PCR amplification, groups molecules sharing common tags. With SSCS, any differences among the reads are discounted as errors, and thus error rates are reduced by 2-3 orders of magnitude. However, errors occurring in the first round of amplification, so-called “jackpot errors”, can propagate to all other copies and cannot be differentiated from true variants. These errors result in a lingering, albeit lower, technical error background. Duplex Sequencing uses a special form of molecular tagging to independently barcode each strand of individual DNA duplexes in such a way that short sequence reads derived from one strand can be related to the other. The theoretical error rate of DS is exceptionally low at <10-9and is uniquely suited to detect adaptive mutability by assessing the scTMB (and possibly the trinucleotide mutation signatures) as an early as possible. 

TwinStrand invented the sequencing process and holds the patent to said process. There is no other company that offers this patented technology. Duplex Sequencing is the most accurate DNA sequencing technology in existence, which was invented by TwinStrand (Dr. Jesse Salk, co-investigator) (41-50), and stands in contrast to conventional methods of NGS, which suffer from limited sensitivity due to biochemical and sequencing errors that obscure variants below frequencies of ~1%.

Submit comments regarding this notice of sole source procurement by filling out the form below prior to the “Comments Due Date” indicated above:

  • (a copy will be sent to this email address)



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Software as a Service for Project Management

Notice Number: 129733862
Date Posted: 2/21/2020
Comments Due: 2/27/2020
at 12:00 PM current Mountain Time.

The Utah Procurement Code provides that a procurement may be made without competition when the University determines that there is only one source that can reasonably meet the University’s need for the required supply or service, as described in Utah Code Ann. § 63G-6a-802.

The Purchasing Department has received the following request for sole source procurement:

Product and/or Service to be purchased: Software as a Service for Project Management
Sole Source Supplier: Oracle
Earliest Proposed Purchase Date: 2/28/2020
Buyer Name: Trent Blair
Sole Source Justification:

This is a software as a service contract for the web-based Primavera Unifier project management system.  The system is used to track and manage 450 – 475 active projects at any given time as well as to serve as an archive of information and documents for completed projects.  The current contract provides for 400 users for the Project Controls Cloud Service and AutoVue 2D Professional Cloud Service which would be increased to 425 users under the extension.  The current contract also provides for 25 users of the Primavera Analytics Cloud Service and this would be included in the extension.  Key features of the system include: System of record for architect/engineer and construction contracts as well as purchase orders issued for construction projects. System of record for all project documents except for payment documents.Integration with PeopleSoft financial system to generate payments through PeopleSoft.Over 75 business processes in place for funding; budgeting; procurement; payments; recording other costs; collaboration with architects, engineers, contractors and clients; scheduling; and building code and customer reviews of plans.Unifier is a very flexible system with substantial capacity to meet unique user requirements such as the University’s needs for somewhat different configurations and business processes for the majority of its projects that are managed entirely by the University versus a small number of very large projects that are jointly managed with a state agency with the state agency holding most contracts and making most payments. The Unifier system was originally acquired through a RFP in 2006 with the contract awarded to Skire, Inc. for $1,000,272 for a 5-year term for 250 users.  Skire was subsequently purchased by Oracle and the current contract and PO with Oracle were issued on Feb. 22, 2016 for 300 users.

Through informal means, the University has explored alternative project management systems. The more robust systems would provide functionality similar to that which the Unifier system currently provides with an annual, ongoing cost similar to Unifier. While these systems have variations in how they are configured and details in their functionality and flexibility, they do not provide substantial enough benefit to the University to come close to offsetting the substantial transitional cost. 
 
While less robust systems may carry a lower ongoing cost and potentially a somewhat lower transitional cost, they would not have the features and flexibility required to meet the University’s needs to address unique University processes as well as the intricacies of supporting both projects managed entirely by the University as well as those jointly managed with a state agency.

Submit comments regarding this notice of sole source procurement by filling out the form below prior to the “Comments Due Date” indicated above:

  • (a copy will be sent to this email address)
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Omnigo Software Renewal

Notice Number: 129111456
Date Posted: 2/20/2020
Comments Due: 2/27/2020
at 12:00 PM current Mountain Time.

The Utah Procurement Code provides that a procurement may be made without competition when the University determines that there is only one source that can reasonably meet the University’s need for the required supply or service, as described in Utah Code Ann. § 63G-6a-802.

The Purchasing Department has received the following request for sole source procurement:

Product and/or Service to be purchased: Omnigo Software Support and Renewal
Sole Source Supplier: Omnigo Software
Earliest Proposed Purchase Date: 2/27/2020
Buyer Name: Colette Brown
Sole Source Justification: Additional and renewal of Omnigo software for five (5) year term.

Submit comments regarding this notice of sole source procurement by filling out the form below prior to the “Comments Due Date” indicated above:

  • (a copy will be sent to this email address)
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RDM (radiation Dose Management) Platform

Comments Due: at 12:00 PM current Mountain Time. The Utah Procurement Code provides that a procurement may be made without competition when the University determines that there is only one source that can reasonably meet the University’s need for the required supply or service, as described in Utah Code Ann. § 63G-6a-802.

Notice Number: SS02192020VA

Date Posted:02/19/2020

The Purchasing Department has received the following request for sole source procurement:

Product and/or Service to be Purchased: RDM (radiation Dose Management) Platform

Sole Source Supplier: SST Group

Earliest Proposed Purchase Date: 02/26/2020

Buyer Name: Valerie Allred

Sole Source Justification: • RDM is the only system that accesses the entire DICOM header and makes this data available for use (rather than exclusively looking at RDSR or secondary capture of the “dose page”. These data are important for calculating dose values, other than ED (which RDSR provides).

Submit comments regarding this notice of sole source procurement by filling out the form below prior to the “Comments Due Date” indicated above:

  • (a copy will be sent to this email address)
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Acquity Arc Bio- 129307260



Notice Number: 129307260
Date Posted: 2/13/2020
Comments Due: 2/20/2020
at 12:00 PM current Mountain Time.

The Utah Procurement Code provides that a procurement may be made without competition when the University determines that there is only one source that can reasonably meet the University’s need for the required supply or service, as described in Utah Code Ann. § 63G-6a-802.

The Purchasing Department has received the following request for sole source procurement:


Product and/or Service to be Purchased: IncuCyte – Imaging equipment for incubators
Sole Source Supplier: Waters/TA Instruments

Earliest Proposed Purchase Date: 2/20/2020
Buyer Name: Anthony Ferrara
Sole Source Justification:

Our HPLC systems are validated and qualified for drug manufacturing by the FDA.  We have substantial man hours and regulatory costs that are associated with replacing and revalidating a replacement system.  These costs are related to validation requirements in 21CFR 212 and Part 11 compliance. This work has already been completed with the current system.  It would take about 6 months of a 1.0 FTE radiochemist and radiopharmacist which adds to about $225,000. 

The cost to transition to a different system is cost prohibitive.  It would cost approximately 2.5 times more than the cost of the proposed equipment just in revalidation of a new replacement system.    
 

Submit comments regarding this notice of sole source procurement by filling out the form below prior to the “Comments Due Date” indicated above:

  • (a copy will be sent to this email address)



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IncuCyte- 120269768

Notice Number: 120269768
Date Posted: 7/8/2019
Comments Due: 7/15/2019
at 12:00 PM current Mountain Time.

The Utah Procurement Code provides that a procurement may be made without competition when the University determines that there is only one source that can reasonably meet the University’s need for the required supply or service, as described in Utah Code Ann. § 63G-6a-802.

The Purchasing Department has received the following request for sole source procurement:


Product and/or Service to be Purchased:
IncuCyte S3 HD/2CLR System Package & Cell-By-Cell Analysis Software Module

Sole Source Supplier: Essen Bioscience

Earliest Proposed Purchase Date: 7/15/2019
Buyer Name: Anthony Ferrara
Sole Source Justification:

The IncuCyte by Sartorius is a real-time, live cell analysis system that captures multiple images of cells during growth and incubation. There are currently no other incubator-specific real-time analysis systems that are comparable to our needs in the lab. Furthermore, Sartorius/Essen Science is the only company with an in-incubator, live cell analysis system in the market. There is no other competition for the IncuCyte in the market today that includes the add-ons for detecting clones, cell-by-cell analysis, and allows for image time points every ten minutes.

Submit comments regarding this notice of sole source procurement by filling out the form below prior to the “Comments Due Date” indicated above:

  • (a copy will be sent to this email address)

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