Date Posted: 6/13/2018
Comments Due: 6/20/2018
at 12:00 PM current Mountain Time.
The Utah Procurement Code provides that a procurement may be made without competition when the University determines that there is only one source that can reasonably meet the University’s need for the required supply or service, as described in Utah Code Ann. § 63G-6a-802.
The Purchasing Department has received the following request for sole source procurement:
Product and/or Service to be Purchased: Global untargeted metabolomics assay
Sole Source Supplier: Metabalon, Inc.
Earliest Proposed Purchase Date: 6/20/2018
Buyer Name: Anthony Ferrara
Sole Source Justification: This project measures metabolites among endometrial cancer cases and matched controls nested within large cohort studies. We require a global untargeted platform with extensive reference standards library.
The assay has beed described: Evans AM BB, Liu Q, Mitchell MW, Robinson RJ, Dai H, Stewart SJ, DeHaven CD, Miller LAD. High
Resolution Mass Spectrometry Improves Data Quantity and Quality as Compared to Unit Mass Resolution
Mass Spectrometry in High-Throughput Profiling Metabolomics. Metabolomics. 2014;4(2):132.
Metabolon Inc’s library of standards covers >1000 chemically identified metabolites per biospecimen, many that are markers of exposures of interest in this study and that are not measured in most other academic or commercial laboratories. The other laboratory commonly used in epidemiological studies (the Broad Institute platform) identifies less than half the number of metabolites per sample. Our project is agnostic and therefore would benefit mostly from a platform that comprehensively captures the human metabolome.
My (Mary C Playdon)previous metabolomics research at the NCI used the Metabolon Inc. platform, thus all preliminary data and reliability pilot information is based on metabolite data from their platform. I will be using blood samples from the NCI and Harvard cohorts. I was required to obtain Biospecimen Committee approval from all cohorts prior to submitting the grant for this project, and they approved my use of the blood samples contingent on us using the Metabolon, Inc. platform.
My R00 project will measure metabolite associations with endometrial cancer, using data from 3 cohorts. However, project is now within the scope of a much larger effort, where the NCI will also be doing similar analyses within additional cohorts. We have an agreement to do a large, pooled meta-analysis of the data, thus we would need to use the same metabolomics platform in order to capture the same panel of metabolites. NCI plans to use Metabolon.
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