The report Brain 2025, a Scientific Vison contains seven priority research areas for the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative. The BRAIN initiative seeks to monitor and modulate brain activity by bringing to bear a number of scientific disciplines including statistics, physics, mathematics, engineering, and computer science as well as neurobiology. The NIH has issued two R01 funding opportunity announcements that address some of the core recommendations of the report.
Foundations of Non-Invasive Functional Human Brain Imaging and Recording – Bridging Scales and Modalities is aimed at recommendations III.2 and 6 of the report dealing with “Maps at Multiple Scales” and “Advancing Human Neuroscience”. Techniques such as functional magnetic resonance imaging (fMRI) have provided a macroscopic understanding of how the human brain responds under a variety of conditions, while invasive techniques such as optogenetics have provided data on small-scale neural interactions in animals. This solicitation seeks to connect the two fields of research with the goal of inferring small scale interactions from the limited data available from non-invasive techniques.
Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain seeks to advance in vivo neuroscience research in by aggregating opportunities and access to human patients. High resolution stimulating/recording data is available for only a limited number of patients. This opportunity is aimed at forming highly interdisciplinary teams across multiple research sites that can access enough patients to develop statistically powerful data sets.